Biography
Stephen Safe is a Distinguished Professor of Toxicology, Department of Veterinary Physiology and Pharmacology at Texas A&M University. Safe has conducted major research into the anti-estrogenic effects of manmade chemicals. He has been a leading critic of the endocrine disruption hypothesis espoused by Theo Colborn and others.
Research Interest
Dr. Safe's research is focused on the molecular biology of cancer cell growth and development of new mechanism-based anticancer drugs, with emphasis in the areas of molecular biology of endocrine disruption chemicals, mechanisms of toxicity, breast cancer including mechanisms and therapeutics, pancreatic, prostate, colon, and bladder cancer including mechanisms of growth and effects of PPARyagonists.
Biography
Dr. Weiqin Chen studied the role of dyslipidemia on diabetic retinopathy, a microvascular complication in diabetic patients with Dr. Julia Busik at Michigan State University and received her PhD degree in Molecular Genetics in 2005. Subsequently, she worked as a Postdoctoral associate for five years with Dr. Lawrence Chan at Baylor College of Medicine, where she was promoted as an instructor in 2010. At BCM, she established two animal models based on genes that are associated with non-alchoholic fatty liver disease (NALFD) and human congenital generalized lipodystrophy (CGL) and characterized their functions in energy metabolism. In 2012, she was recruited as an Assistant Professor in the Department of Physiology at Georgia Regents University. The focus of her current research is to dissect the mechanisms underlying adipose tissue dysfunction and development of obesity and lipodystrophy using both in vivo and in vitro strategies.
Research Interest
besity and its associated health comorbidities are a worldwide epidemic with serious economic and health burden on society. Adipose tissue is an important endocrine organ that plays a key role in the development of obesity and various metabolic disorders. White adipocytes store excess energy in the form of triglycerides for future need. By contrast, brown and beige (browning-in-white) adipocytes metabolize lipid and glucose to produce heat in a process known as nonshivering thermogenesis, which is crucial in systemic energy homeostasis and thermoregulation. Functional brown and beige adipose tissues are highly correlated with body mass index in adult humans and is either reduced or absent in obese and aged individuals and rodents. The long-term research interest in the lab is to understand the regulation of white, beige and brown adipose tissue development and energy homeostasis, and use it to develop potential therapeutic approaches for obesity and related metabolic diseases.
Biography
Jose Mario is the Deputy Editor for Diabetes at the Community Forum of healthcare professionals in British Medical Journal. He is an Associate Professor in the Department of Medicine at Universidade Federal Fluminense, and a Senior Staff Physician in the Intensive Care Unit-Adults at Hospital Federal da Lagoa, all in Rio de Janeiro, Brazil. He also has been a principal investigator, and has published clinical studies & Letters to Editors about the mechanisms of cardiovascular diseases associated with type 2 diabetes mellitus in peer reviewed journals like British Medical Journal, Hypertension, New England Journal of Medcine, and American Journal of Hypertension. He was also a post-doctoral Clinical & Research Fellow in the Endocrinology-Diabetes and Hypertension Division of the Brigham & Women´s Hospital at Harvard Medical School where he did many angiotensin II infusions in humans, normotensive, hypertensive, and diabetic individuals. When at Harvard Medical School, he also became certified in the Principles of Epidemiology by the Harvard School of Public Health. He expect for the newer future better prevention and treatment strategies for macrovascular and microvascular diabetic complications, based on more rational and effective strategies. In the University, he is proud of running a busy Hypertension and type 2 diabetes clinic. At British Medical Journal, he enjoy the freedom and internationality of opinions. And also expect a brighter debate about all the clinical future research pathways and controversies surrounding diabetes mellitus.
Research Interest
He has a special interest in type 2 Diabetes, Preventive Cardiology, Hypertension, the renin-angiotensin-aldosterone system and Cardiovascular Diseases associated with Chronic Kidney Diseases.
