Matteo Mariano
ASL FG Teresa Masselli Mascia Hospital, Italy
Title: Craniopharyngioma and hypothalamic hamartoma: auxo-endocrinology changes to diagnosis and endocrine complications after surgical and/or medical treatment.
Biography
Biography: Matteo Mariano
Abstract
The craniopharyngioma and hypothalamic hamartoma are two tumors location in the brain (above)saddle and hypotalamus, with a histologically benign but uncertain behavior. Aim of the study: to value auxo-endocrinological changes to the diagnosis and after surgical and/or medical treatments. Matherial and method: mean of follow-up 7.0±5.2 years. Were studied 25 babies with craniopharyngioma and 1 baby with hypothalamic Hamartoma. For each subject, at diagnosis and during follow-up were detected at least once a year: Height (H),Weight (W) Pubertal development (In females: breast (B), Pubic Hair (PH), Menarche ; in the male: Genital (G), Pubic Hair (PH), Vol.Testicolare). H and W were evaluated by the standards of Tanner et al.; mass index (BMI) was evaluated with the standards of Rolland- Cacher etal. pubertal development was assessed by the standards of Marshalland Tanner. Endocrine features: baseline and / or after stimulation of GH, IGF-I, TSH, FT4, PRL, ACTH, cortisol, DEAS, insulin, E2, T, LH and FSH in pubertal Serum electrolytes, plasma osmolality and urinary. Conclusion: despite adequate replacement therapy, children with craniopharyngioma leave open several issues: High incidence of short stature 2DS (6 / 25 cases) High incidence of obesity (15/25 cases) Marked hyperphagia (binge eating) with difficulty in controlling appetite Increased behavioral disorders and psychosocial. The baby with hypothalamic hamartoma showed only hyperactivity during follow-up.