Kiran V Sandhu
Otto-von-Guericke University, Germany
Title: Phytoestrogen, as a treatment in the psychiatric condition with altered social and emotional behaviors
Biography
Biography: Kiran V Sandhu
Abstract
Dietary phytoestrogens affects spectrum of social, emotional and cognitive behavior with beneficial effects towards anxiety and affective disorders. Here, I reported the effect of phytoestrogens in the regulation of social and emotional behavior which is often known to be affected in psychiatric condition. Additionally, the role of phytoestrogens in the regulation of Glutamic acid decarboxylase (GAD), a rate-limiting enzyme which is often associated with various psychiatric disorders. Phytoestrogens were dietary administered post-weaning through commercial diet consisting each of 150 mg/kg Daidzein and Genistein. Male mice showed disturbance in social and emotional behavior when phytoestrogen was removed from their diet for a period of 6 weeks. These animals showed disrupted social behavior, aggression and altered urine marking pattern. They also displayed reduced sensitivity to both social and non-social odors. In the fear-memory-paradigm the male mice showed altered freezing response to the contextual paradigm. Further, I investigated the role of phytoestrogens in the regulation of GAD. High resolution microdissection showed increase in GAD67 and 65 expression with phytoestrogens. GAD67-GFP quantification showed a similar increase in gene activity in different subregions of amygdala with phytoestrogens in GAD67+/- male mice. Thus the output therefore suggests, phytoestrogens as a possible treatment for various psychiatric disorders like Schizophrenia, Autism and Bipolar disorders with altered social and emotional behaviors.