Marco Antônio Peliky Fontes
Universidade Federal de Minas Gerais, Brazil
Title: The descending sympathetic pathways from dorsomedial hypothalamus: critical links to understand stress-related and obesity-related cardiovascular diseases
Biography
Biography: Marco Antônio Peliky Fontes
Abstract
Maintenance of homeostasis depends upon mechanisms controlling autonomic output. Sympathetic output depends on neuronal activity from different brain regions. Central requirement for changes in sympathetic output must be adjusted to the input signals from neural and humoral factors for an optimum cardiovascular performance. Consequently, abnormal inputs to one or more brain regions involved in the sympathetic control can lead to cardiovascular disease. Contributing factors may involve; abnormal feedforward and feedback mechanisms and altered humoral factors including angiotensinergic and leptinergic inputs. The dorsomedial hypothalamus is a key central region for the control of sympathetic outflow to the cardiovascular system. Recently, the descending sympathetic pathways from dorsomedial hypothalamus have been revealed. Reviewing the descending pathways from dorsomedial hypothalamus we discuss the interactions between mechanisms controlling the sympathetic output to the cardiovascular system and the possible implications in cardiovascular disease. Support: CNPq, FAPEMIG, CAPES.