Chirag Prajapati
Hemchandracharya North Gujarat University, India
Title: Lonicera japonica protects spargue-dawley rat against 11β-HSD1 induced endothelial dysfunction in metabolic syndrome
Biography
Biography: Chirag Prajapati
Abstract
Objective: To study the pharmacological evaluation of Lonicera japonioca with reference to metabolic syndrome in order to restore 11β-HSD1 induced endothelial dysfunction in SD rats.
Introduction: Metabolic syndrome is multidisciplinary metabolic disorder in which Diabetes Mellitus, Hypertension and Obesity are presented jointly. Chlorogenic acid is a major bioactive component in the flower buds of Lonicera japonica having 11β-HSD1 property. 11β-HSD1 induced endothelial dysfunction has been postulated to be a major contributor to the pathogenesis of Metabolic Syndrome.
Methods: Present studies were aimed towards investigating the effectiveness of this LJALE extract against STZ-HFD induced diabetes and associated complications, fructose induced hypertension and HFD induced obesity respectively using SD rats. Parameters like ex vivo 11β-HSD 1 inhibition assay, vascular reactivity study, Nitric Oxide and Peroxynitrile have been measured.
Results: Chlorogenic acid isolated from LJALE could dose dependently inhibit the 11β-HSD1 activity. LJALE attenuate the 11β-HSD1 induced endothelium dysfunction in rats. LJALE treated obese animal reflect significant increased Nitric oxide and decreased Peroxynitrile.
Conclusion: From all above statements, it has been concluded that Lonicera japonica protects SD rats against 11β-HSD1 induced endothelium dysfunction in Metabolic Syndrome.