Endocrinology

Biography

Biography: Jaideep Khare

Abstract

Polycystic Ovary Syndrome (PCOS) is most common cause of anovulatory infertility, present in 5-10% women of reproductive age. Many of these patients require assistance for reproduction in form of ovulation induction alone (OI), ovulation induction with intrauterine insemination (IUI) or assisted reproductive technology like IVF. In this prospective observational study, we have tried to find out the fertility outcome in these patients treated with different assisted reproductive procedures. In total, 115 patients were allocated to OI, IUI or IVF groups. Mean age, BMI and infertility duration was 28.26±4.58 years, 26.93±3.84 kg/m² and 4.20±2.91 years, respectively. OI group included 25 patients who received 40 OI cycles. Total Pregnancy (TP) and Ongoing Pregnancy (OP) rate per OI treatment cycle was 27.5% and 17.5%, respectively and overall TP and OP rate was 44% and 28%, respectively. IUI group included 56 patients who received 89 IUI cycles. TP and OP rate per IUI cycle was 21.35% and 15.73%, respectively and overall TP and OP rate was 33.93% and 25% respectively. IVF group included 34 patients who received 47 fresh IVF cycles and 19 frozen embryo transfer cycles. The cumulative pregnancy rate and OP rate in IVF group was 73.53% and 55.88%, respectively. Ovarian hyperstimulation syndrome as a complication was seen in one patient of IVF and two patients of IUI group, whereas multiple pregnancies and ectopic pregnancy was seen in one patient each in IVF group. Amongst three methods of assisted reproduction, IVF is most effective treatment for infertility but because it is more invasive and more expansive it should be last resort if earlier methods fail.