Day :
Location: .
Chair
Si Nae Kang
Seoul National University Hospital
Session Introduction
Xinjun Jiang
Peking University, China
Title: Evaluation of Self-Efficacy Educational Interventions in Patients with Diabetes: A Systematic Review
Biography:
Xinjun Jiang is a PhD candidate in Nursing School, Peking University. Her research area is about the diabetes self-management education for persons with diabetes. Now she is conducting a culturally sensitive diabetes education program in China, with the purpose of helping persons with diabetes change behaviour and keep desirable results in blood glucose levels.
Abstract:
Purpose: The purpose of this study is to evaluate the effectiveness of diabetes self-efficacy educational interventions in patients with diabetes and to determine the effective components of the interventions. Methods: Six databases were systematically searched for studies on the metabolic controls, diabetes self-efficacy, behaviour, knowledge, psychological indicators and quality of life of diabetes self-efficacy educational interventions for patients with diabetes. Sixteen studies published between 2006 and 2017 met the inclusion criteria. Results: Glycosylated haemoglobin A1C, fasting blood glucose, diabetes self-efficacy, behaviour and knowledge were identified as positive results in most studies. Only five studies used the complete four sources of information, and eight studies assessed both the self-efficacy and behaviour of participants based on self-efficacy theory. Performance accomplishments, vicarious experience and verbal persuasion were predominantly employed. Such strategies as goal setting, practicing self-management skills, participants’ return-demonstration, behaviour recording, peer modelling, verbal persuasion by nurses and face to face delivery were preferred in the included studies. Conclusions: Individuals with diabetes are likely to benefit from diabetes self-efficacy educational interventions. The four sources of information and outcome assessments based on self-efficacy theory were insufficient in most studies. Future work is required to develop an effective diabetes self-efficacy educational intervention and further determine the effects.
Shuhang Xu, Chao Liu
Nanjing University of Traditional Chinese Medicine, China
Title: Metformin and thyroid diseases: a new perspective to understande the relevance of metabolism and thyrod disease
Biography:
An intriguing area of research in thyroidology is the recently discovered association of insulin resistance with thyroid functional and morphological abnormalities. Individuals with hyperinsulinemia have larger thyroid gland and a higher prevalence of thyroid nodules and cancer. Accordingly, patients treated with metformin have a smaller thyroid volume and a lower risk of incident goiter, thyroid nodule and cancer. Multiple studies in vitro and in vivo have demonstrated that metformin can inhibit the growth of thyroid cells and different types of thyroid cancer cells by affecting the insulin/IGF1 and mTOR pathways. Besides, metformin treatment was associated with a decrease in the levels of serum thyroid-stimulating hormone (TSH) in diabetic patients possibly by enhancing the effects of thyroid hormones in the pituitary and activating the adenosine monophosphate-activated protein kinase (AMPK). Based on this evidence, metformin appears to be a promising therapeutic tool in patients with thyroid disease. More clinical studies are necessary to evaluate the clinical significance of metformin for the treatment of thyroid diseases.
Abstract:
Shuhang Xu has completed his MD from Humbolt University in 2013. He is the associate cheif doctor of the department of Diabetes and Endocrinology, Jiangsu Province Hospital on Integration of Chinese and Western Medicine. He has published more than 20 papers in reputed journals and has been active in thyroid field in China.
Session Introduction
Si Nae Kang
Seoul National University College of Medicine
Title: The association between risk of metabolic syndrome and occupational, leisure-time and commuting physical activity in Korean workers: KNHANES 2014-2016
Biography:
Si Nae Kang is medical doctor specialized in Family Medicine, currently has been research fellow in Department of Family Medicine, Seoul National University Hospital, with experience in research, evaluation, teaching . She has special interest in Health promotion and Public health and conducted research on Korean smokers last year. She has developed pilot project of visiting care system for elderly, that is operated successfully now.
Abstract:
While the relationship of leisure time physical activity (LPA) and metabolic syndrome (MetS) is well documented, effect of occupational physical activity (OPA) on MetS is conflicting. Aim of this study is to examine the relationship between different type of physical activity and risk of metabolic syndrome using a representative sample of South Korean adults.
Study included 7057 workers (3795 men and 3262 women) aged 20 to 65 without cancer and arthritis at baseline, from the Korea National Health and Nutrition Examination Survey in 2014-2016. Information on OPA, LPA and commuting physical activity (CPA) were self-reported and blood pressure and biochemical determinations of the blood were also obtained. MetS was defined as the presence of three or more of the National Cholesterol Education Program-Adult Treatment Panel III criteria. Chi-square test and multiple logistic regression analysis were used to investigate relationship between different type of physical activity and MetS.
The prevalence of MetS was 25.7 % in the study subject. The percentages of active OPA in MetS and non-MetS groups were 6.7% and 5.0%, respectively. Compared with inactive level of LPA, sufficient level of LPA showed a significantly lower risk of MetS (OR 0.73, 95% CI 0.60-0.89) after adjustment for confounding factors. Conversely, active OPA showed increased risk of MetS (OR 1.09, 95% CI 0.77-1.52), but not reaching statistical significance. CPA was not associated with MetS.
LPA showed protective effect of MetS, but OPA showed marginal negative effect on MetS. This difference needs to be considered when recommendations for prevention of MetS are developed.
Gong Deuk Bae
Lee Gil Ya Cancer and Diabetes Institute
Title: Effect of liquiritigenin on apoptotic beta-cell death by palmitate-induced lipotoxicity in INS-1 cells
Biography:
Gong Deuk Bae is a PhD course student in Gachon university. His research topic is The effect of natural products on the prevention and treatment of type 2 diabetes focusing on pancreatic beta-cells.
Abstract:
Objective: Activation of estrogen receptor signaling plays an important role to preserve functional beta‑cell mass in treatment of diabetes. Liquiritigenin (LQ), a flavonoid isolated from Glycyrrhiza uralensis, is an estrogenic compound which acts as an agonist for the estrogen receptor β. In this study, we investigated protective effect of LQ on palmitate (PA)-induced apoptosis in INS-1 cells.
Methods: To examine effect of LQ on beta cells, glucose stimulated insulin secretion (GSIS) by enzyme immunoassay (EIA) method and cell viability by MTT were measured in rat beta-cell line INS-1 cells. To induce lipotoxicity, PA (400 μM) was treated for 24 h and amount of apoptotic cells were analyzed using a flow cytometer with annexin-V staining. Expression level of apoptotic proteins and endoplasmic reticulum (ER) stress markers were analyzed by western blot analysis after LQ treatment. Tunicamycin and thapsigargin were used to ER stress inducer and AKT inhibitor (AKTi-1/2) was used to inhibit LQ-induced AKT phosphorylation at ser 473.
Results: Exposure of INS-1 cells to 5 μM of LQ significantly increased GSIS as well as cell viability. PA treatment increased annexin-V stained cells and apoptotic proteins such as cleaved caspase-3, cleaved poly (ADP-ribose) polymerase and bax, but these increases were significantly inhibited by LQ treatment. LQ treatment inhibited cell death by ER stress inducers and PA induced ER stress marker proteins such as CHOP and phosphorylated forms of PERK and eIF2α was also significantly downregulated in LQ treated cells. LQ phosphorylated AKT at ser 473 via estrogen receptor element dependent pathway and blocking AKT signaling inhibited LQ induced decrease in level of phosphorylated PERK, consequently cell viability was not recovered.
Conclusion: Our data demonstrated that LQ has anti-apoptotic effect against PA induced lipotoxicity and AKT mediated ER stress inhibition was involved in the anti-apoptotic effect of LQ.
Philip James
W. P. Carey School of Business -Arizona State University, USA
Title: What every doctor needs to know about personal branding: 2019 and beyond
Biography:
Philip James is a marketing and communications consultant to the medical and architecture industries. Philip is an expert at building narratives and personal brands. His clients include hospitals, physicians, and industry associations. He has worked at ENDO, and the World Congress on Thyroid Cancer.
Abstract:
In this case, branding isn’t necessarily about logos and taglines. Simply put, a physician’s brand is essentially equal to his or her reputation. What patients think about you, how well-known you are in your community, your online presence–that is your brand. More and more patients are turning to online sources to find a physician. They may look at your website, but they are also likely consulting online reviews and listings as well. Branding is more important than ever if you want to attract the attention of these patients, whether you are just starting out or are already an established physician. During this session, the following topics will be covered:
- Five steps to brand building
- How to use digital tools and social platforms
- The danger of doing nothing
- Case Study: Dr. Netterville